Recognize
- Laboratory abnormalities (elevated creatinine, electrolyte abnormalities)
 - Urinalysis abnormalities (casts)
 - Abdominal or pelvic disease that could be causing symptoms
 - Prior history of renal compromise?
 - Other immune-related adverse effects?
 - Presence of current or prior immune-mediated toxicities, including rhabdomyolysis
 - Is patient volume depleted?
 
																				
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