Monitoring for toxicty

[Krista Rubin]

What is your standard for cardiotoxicity monitoring with dual BRAF/MEK inhibitor therapy. How often are you obtaining EKGs/ECHOs?

[Kathleen Madden]

Baseline before or onset of therapy EKG & echo (if pt had a recent one with in several months- will obtain that info) if no echo on file- will send pt for baseline echo, but would not delay start of therapy
2 weeks after start of therapy- EKG
1 month after start of therapy- EKG
2 months after start of therapy- Ekg & Echo if any susupicous sx, prior EKG changes or extensive cardiac history
Typically if a patient is doing well we will then perform an EKG every 12 weeks in cadence with scans
Echo q 6- 12 months

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