CTCAE Grading for Eye Pain

  • Asymptomatic or mild symptoms; intervention not indicated
  • Symptomatic; topical interventions indicated (e.g., antibiotics); limiting instrumental ADLs
  • Limiting self-care ADLs


  • Encourage patient to report any eye symptom immediately
  • Obtain ophthalmology referral
  • Anticipate ipilimumab holds for any Grade 2 AE; resume when returns to G0 or 1; permanently discontinue for any G3 AE, persistent G2 AE lasting ≥6 weeks, or inability to reduce corticosteroid dosage to 7.5 mg/d prednisone or equivalent