We tend to be creatures of habit as well and really only look to switch to other BRAF-MEK combos if there might be decreased incidence of side effects. For example, if someone has horrid fevers from Taf-Mek, we’ve tried Vem-cobi. I do believe that this newer (third) combo coming to market has a lower incidence of certain AEs with similar efficacy, so it can likely find its place and be utilized. And I hope that competition will help control costs -always an issue and one we deal with so commonly with oral meds.