Hi everyone,
I am wondering if anyone has a suggestion for ipilimumab (10 mg/kg dose) induced ileitis/colitis that has been refractory to both oral and IV steroids as well as three doses of infliximab. We have been treating her since May on steroids for this issue. We wanted to give vedolizumab as there are some reports of this being used in these cases, but her insurance company will not pay for it (despite a peer to peer review and referenced articles). We have consulted the GI team, but they do not have any other suggestions. We are planning to give another dose of infliximab, but if anyone has a different suggestion, I would welcome it!

Best,
Virginia